Physical Organic Chemistry
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Die Vorlesung findet immer montags von 10:00 bis 11:30 Uhr in Hörsaal 52-203 statt. Sie beginnt am 21.10.2024. Weitere Informationen zur Vorlesung finden Sie im OpenOLAT Kurs.
Studiengang: Master Chemie
KIS Office: Link
OpenOLAT: https://olat.vcrp.de/url/RepositoryEntry/2782396929
Modulverwendung: Die Vorlesung kann in die Vertiefungsfelder "Reactivity, Catalysis and Sustainability" und "Life Science and Bioanalytics" eingebracht werden. Die Unterrichtssprache ist Englisch.
Kurskennung: CHE-MM-Ch-VM24-M-7
Studiensemester: jedes
Semesterwochenstunden: 3
ECTS: 4
Content
Physical organic chemistry is a branch of organic chemistry that deals with the relationship between the structure of organic molecules and their reactivity. The first part of the lecture covers thermodynamic and kinetic aspects of organic reactions and concepts for correlating structure and reactivity. After a short summary of the key concepts of molecular orbital theory, the different classes of pericyclic reactions and their stereoselectivity are explained. The last part of the lecture deals with photochemical reactions.
| 1. | Introduction |
| 1.1 | Potential energy curves and surfaces |
| 1.2 | Transition state theory |
| 1.3 | Thermodynamic vs. kinetic control |
| 2. | Reactivity models |
| 2.1 | Hammond’s postulate |
| 2.2 | Bell-Evans-Polanyi principle |
| 2.3 | Curtin-Hammett principle |
| 2.4 | Reactivity-selectivity principle |
| 2.5 | Solvent effects |
| 3. | Structure-reactivity correlations |
| 3.1 | Electronic and stereoelectronic effects |
| 3.2 | Isotope effects |
| 3.3 | HSAB principle |
| 3.4 | Linear free-energy relationships |
| 3.4.1 | Hammett |
| 3.4.2 | Taft |
| 4. | MO Theory |
| 4.1 | Basics |
| 4.2 | HMO Theory |
| 4.3 | FMO Theory |
| 5. | Pericyclic reactions |
| 5.1 | Electrocyclic reactions |
| 5.2 | Cycloadditions |
| 5.3 | Sigmatropic rearrangements |
| 5.4 | Cheletropic reactions |
| 5.5 | En-reactions |
| 6. | Photochemistry |
Literature
- H. Zipse, Reactivity and Mechanism in Organic Chemistry, Shaker Verlag, Düren, 2020
- E. V. Anslyn, D. A. Dougherty, Modern Physical Organic Chemistry, University Science Books, Sausalito, CA, 2004
- F. A. Carey, R. J. Sundberg, Organische Chemie, Wiley-VCH, Weinheim, 1995
- I. Fleming, Grenzorbitale und Reaktionen Organischer Verbindungen, Wiley-VCH, Weinheim, 1998
- N. S. Isaacs, Reactive Intermediates in Organic Chemistry, Wiley, New York, 1974
- T. H. Lowry, K. Richardson, Mechanismen und Theorie in der Organischen Chemie, Verlag Chemie, Weinheim, 1980